The article examines the surprising role of Rousseau in the revival of liberal and humanist thought in contemporary French political thought. The choice of Rousseau as an inspiration and source of humanism is an illuminating indication of a shift in French thought. The authors concentrate on the natural- rights republicanism of Luc Ferry and Alain Renaut and the critical humanism of Tzvetan Todorov. While these thinkers all appeal to Rousseau's definition of humanity in terms of freedom, they draw on different (...) aspects of his thought and his relationship to the philosophic tradition. Their different receptions of Rousseau reveal tensions in the humanist revival and provoke reflection on the relationships among republicanism, liberalism and humanism in contemporary France. (shrink)

Emotional stimuli are consistently better remembered than neutral stimuli. However, the reported effects of emotional stimuli on source memory are less consistent. In four experiments, we examined spatial and temporal source memory and free recall for emotional words previously studied in an fMRI experiment. In the fMRI experiment, the unpleasant but not the pleasant words were shown to activate the amygdala. In the experiments reported here, spatial and temporal source memory were reduced for the unpleasant words compared to pleasant and (...) neutral words. Reduced spatial memory for unpleasant words was observed across studies that varied the specific stimuli, task conditions, and incidental versus intentional encoding instructions. Free recall was enhanced for the pleasant and unpleasant words compared to neutral words. The results demonstrate reduced source memory for unpleasant words even when item recall is enhanced. Our findings are consistent with prior reports of amygdala-mediated amnestic effects evoked by unpleasant stimuli. (shrink)

Image-making is a nearly universal human behavior, yet the visual strategies and conventions to represent things in pictures vary greatly over time and space. In particular, pictorial styles can differ in their degree of figurativeness, varying from intersubjectively recognizable representations of things to very stylized and abstract forms. Are there any patterns to this variability, and what might its ecological causes be? Experimental studies have shown that demography and the structure of interaction of cultural groups can play a key role: (...) the greater the degree of contact with other groups, the more recognizable and less abstract are the representations. Here we test this hypothesis on a real-world dataset for the first time. We constructed a balanced database of Indigenous Australian rock art motifs from both isolated and contact Aboriginal groups (those often in contact with other groups). We then ran a survey asking participants to judge the recognizability of the motifs and to provide interpretations. Results show that motifs from contact Aboriginal groups were more likely to be judged as inter-subjectively recognizable and also elicited more convergent descriptions than motifs from isolated groups. This is consistent with the idea that intergroup contact is likely to be an important factor in the cultural evolution of pictorial representation. We discuss the implications of these findings for the archaeology and anthropology of art, and the parallels with language evolution. (shrink)

Though there are many factors that contribute to the perceived legitimacy of business ethics education, this research focuses on one factor that is given great attention both formally and informally in many business schools: student satisfaction with the course. To understand the nature of student satisfaction, the authors draw from multiple theories with central claims relating expectations with satisfaction. The authors then compare student expectations of business ethics courses with instructor objectives and discover that business ethics courses are not necessarily (...) designed to meet student expectations. The authors speculate that this general mismatch between student expectations and instructor objectives has material consequences. As one example, the authors analyze student evaluations from three business schools and identify a “business ethics course effect”: a negative association between business ethics courses and student evaluations. The authors discuss the implications for business ethics education of a situation where pedagogical objectives and market prescriptions point in different directions. (shrink)

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

Why do otherwise well-intentioned managers make decisions that have negative social or environmental consequences? To answer this question, the authors combine the literature on construal level theory with the compromise effect to explore the circumstances that lead to seemingly unethical decision-making. The results of two studies suggest that the degree to which managers make high-risk tradeoffs is highly influenced by how they mentally represent the decision context. The authors find that managers are more likely to make seemingly unethical tradeoffs when (...) psychological distance is high (rather than low) and when they are forced to choose between competing alternatives. However, when given the option not to choose, managers better reflect on the consequences of each alternative, and thus become more likely to choose options with less risk of negative consequences. The results suggest that simply offering managers the option not to choose may reduce psychological distance and help organizations avoid seemingly unethical decision-making. (shrink)

This paper argues that professionals who make boundary-related decisions should be guided by relationship-based practice. In our roles as service users and professionals, drawing from our lived experiences of professional relationships, we argue we need to move away from distance-based practice. This includes understanding the boundary stories and narratives that exist for all of us – including the people we support, other professionals, as well as the organisations and systems within which we work. When we are dealing with professional boundary (...) issues, we should centre relationship-building skills that are central to many other aspects of our work. Skills that foster relationships at all levels – between professionals, service users, and services – need to be revalued. Our final recommendation is to create, develop, and foster safer spaces within and outside of organisations, as well as inter-professionally, for the discussion and exploration of boundary-related issues and practice. We are interested in hearing from those with experiences of being marginalised by boundaries so that they can inform a reshaping of our collective ideas around boundary related practices. To foster relationship-based practices in organisations, we have outlined several recommendations here; however, we recognize that these do not go far enough, and that collective action is needed to inform systemic change. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Frontiers of Consciousness is a study of the problem of consciousness in a historic period of revolutionary change, and an authentic example of “interdisciplinary studies.” The book contains a wealth of insight into the conceptual interrelationships between the work of the American philosophers who have been called the Builders (William James, Josiah Royce, Charles Peirce, and John Dewey) and the work of three great modernist poets (T. S. Eliot, Wallace Stevens, and William Carlos Williams).

The greatest philosopher of the twentieth century may not have been Wittgenstein, or Russell, or Quine (and he certainly wasn’t Heidegger), but he may have been a somewhat obscure and conservative Australian named David Stove (1927-94). If he wasn’t the greatest philosopher of the century, Stove was certainly the funniest and most dazzling defender of common sense to be numbered among the ranks of last century’s thinkers, better even—by far—than G. E. Moore and J. L. Austin. The twentieth century was (...) not a period in which philosophers distinguished themselves as essayists, or even as capable of writing interestingly on any subject outside their speciality (or even within it). Stove, though, was an essayist, polemicist, and wit of the highest order, rather like a super-intelligent H. L. Mencken. A heavyweight admirer was once led to write that “Reading Stove is like watching Fred Astaire dance. You don’t wish you were Fred Astaire, you are just glad to have been around to see him in action.”. (shrink)

A number of philosophers think that grounding is, in some sense, well-founded. This thesis, however, is not always articulated precisely, nor is there a consensus in the literature as to how it should be characterized. In what follows, I consider several principles that one might have in mind when asserting that grounding is well-founded, and I argue that one of these principles, which I call ‘full foundations’, best captures the relevant claim. My argument is by the process of elimination. For (...) each of the inadequate principles, I illustrate its inadequacy by showing either that it excludes cases that should not be ruled out by a well-foundedness axiom for grounding, or that it admits cases that should be ruled out. (shrink)

Realists about universals face a question about grounding. Are things how they are because they instantiate the universals they do? Or do they instantiate those universals because they are how they are? Take Ebenezer Scrooge. You can say that Scrooge is greedy because he instantiates greediness, or you can say that Scrooge instantiates greediness because he is greedy. I argue that there is reason to prefer the latter to the former. I develop two arguments for the view. I also respond (...) to some concerns one might have about the view defended. I close by showing that analogous views regarding the truth of propositions and the existence of facts are supported by analogs of one of these arguments. (shrink)

What are words? What makes two token words tokens of the same word-type? Are words abstract entities, or are they (merely) collections of tokens? The ontology of words tries to provide answers to these, and related questions. This article provides an overview of some of the most prominent views proposed in the literature, with a particular focus on the debate between type-realist, nominalist, and eliminativist ontologies of words.

Kit Fine (2000) breaks with tradition, arguing that, pace Russell (e.g., 1903: 228), relations have neither directions nor converses. He considers two ways to conceive of these new "neutral" relations, positionalism and anti-positionalism, and argues that the latter should be preferred to the former. Cody Gilmore (2013) argues for a generalization of positionalism, slot theory, the view that a property or relation is n-adic if and only if there are exactly n slots in it, and (very roughly) that each slot (...) may be occupied by at most one entity. Slot theory (and with it, positionalism) bears the full brunt of Fine's (2000) symmetric completions and conflicting adicities problems. I fully develop an alternative, plural slot theory (or pocket theory), which avoids these problems, key elements of which are first considered by Yi (1999: 168 ff.). Like the slot theorist, the pocket theorist posits entities (pockets) in properties and relations that can be occupied. But unlike the slot theorist, the pocket theorist denies that at most one entity can occupy any one of them. As a result, she must also deny that the adicity of a property or relation is equal to the number of occupiable entities in it. By abandoning these theses, however, the pocket theorist is able to avoid Fine's problems, resulting in a stronger theory about the internal structure of properties and relations. Pocket theory also avoids a serious drawback of anti-positionalism. (shrink)

Partial grounding is often thought to be formally analogous to proper parthood in certain ways. Both relations are typically understood to be asymmetric and transitive, and as such, are thought to be strict partial orders. But how far does this analogy extend? Proper parthood is often said to obey the weak supplementation principle. There is reason to wonder whether partial grounding, or, more precisely, proper partial grounding, obeys a ground-theoretic version of this principle. In what follows, I argue that it (...) does not. The cases that cause problems for the supplementation principle for grounding also serve as counterexamples to another principle, minimality, defended by Paul Audi. (shrink)

There are at least three vaguely atomistic principles that have come up in the literature, two explicitly and one implicitly. First, standard atomism is the claim that everything is composed of atoms, and is very often how atomism is characterized in the literature. Second, superatomism is the claim that parthood is well-founded, which implies that every proper parthood chain terminates, and has been discussed as a stronger alternative to standard atomism. Third, there is a principle that lies between these two (...) theses in terms of its relative strength: strong atomism, the claim that every maximal proper parthood chain terminates. Although strong atomism is equivalent to superatomism in classical extensional mereology, it is strictly weaker than it in strictly weaker systems in which parthood is a partial order. And it is strictly stronger than standard atomism in classical extensional mereology and, given the axiom of choice, in such strictly weaker systems as well. Though strong atomism has not, to my knowledge, been explicitly identified, Shiver appears to have it in mind, though it is unclear whether he recognizes that it is not equivalent to standard atomism in each of the mereologies he considers. I prove these logical relationships which hold amongst these three atomistic principles, and argue that, whether one adopts classical extensional mereology or a system strictly weaker than it in which parthood is a partial order, standard atomism is a more defensible addition to one’s mereology than either of the other two principles, and it should be regarded as the best formulation of the atomistic thesis. (shrink)

Speaks defends the view that propositions are properties: for example, the proposition that grass is green is the property being such that grass is green. We argue that there is no reason to prefer Speaks's theory to analogous but competing theories that identify propositions with, say, 2-adic relations. This style of argument has recently been deployed by many, including Moore and King, against the view that propositions are n-tuples, and by Caplan and Tillman against King's view that propositions are facts (...) of a special sort. We offer our argument as an objection to the view that propositions are unsaturated relations. (shrink)

Once one accepts that certain things metaphysically depend upon, or are metaphysically explained by, other things, it is natural to begin to wonder whether these chains of dependence or explanation must come to an end. This essay surveys the work that has been done on this issue—the issue of grounding and infinite descent. I frame the discussion around two questions: (1) What is infinite descent of ground? and (2) Is infinite descent of ground possible? In addressing the second question, I (...) will consider a number of arguments that have been made for and against the possibility of infinite descent of ground. When relevant, I connect the discussion to two important views about the way reality can be structured by grounding: metaphysical foundationalism and metaphysical infinitism. (shrink)

Maureen Donnelly’s (2016) relative positionalism correctly handles any fixed arity relation with any symmetry such a relation can have, yielding the intuitively correct way(s) in which that relation can apply. And it supplies an explanation of what is going on in the world that makes this the case. But it has at least one potential shortcoming — one that its opponents are likely to seize upon: it can only handle relations with fixed arities. It is unable to handle relations with (...) variable arities. I argue that, all else being equal, relative positionalism ought nonetheless to be preferred to its closest competitors — at least to the extent that the explanation it supplies of relational application is plausible — even though those competitors can handle variable arity relations in addition to fixed arity relations. (shrink)

Philosopher's zombies are hypothetical beings behaviorally, functionally, and perhaps even physically indistinguishable from normal humans, but who lack our consciousness. Many people seem to be convinced that such zombies are a real conceptual possibility, and that this bare possibility entails that understanding human consciousness must remain forever beyond the reach of science. However, the conceptual entailments of zombiehood have not been sufficiently examined. This brief article shows that any way of understanding the behavior of zombies that does in fact support (...) the suggested entailment, leads to contradictions and absurdities. Zombies are _not_ conceptually possible. (shrink)

Natural languages differ from most formal languages in having a partial, rather than a total, semantic interpretation function; e.g., some noun phrases don't refer. The usual semantics for handling such noun phrases (e.g., Russell, Quine) require syntactic reform. The alternative presented here is semantic expansion, viz., enlarging the range of the interpretaion function to make it total. A specific ontology based on Meinong's Theory of Objects, which can serve as domain on interpretation, is suggested, and related to the work of (...) Castaneda, Frege, Katz and Fodor, Parsons, and Scott. (shrink)

Natural languages differ from most formal languages in having a partial, rather than a total, semantic interpretation function; e.g., some noun phrases don't refer. The usual semantics for handling such noun phrases (e.g., Russell, Quine) require syntactic reform. The alternative presented here is semantic expansion, viz., enlarging the range of the interpretaion function to make it total. A specific ontology based on Meinong's Theory of Objects, which can serve as domain on interpretation, is suggested, and related to the work of (...) Castaneda, Frege, Katz and Fodor, Parsons, and Scott. (shrink)

The observations which are compatible with temporal origins of the earth, the solar system and the universe are briefly mentioned, prior to examining the assumptions implicit in the hypothesis of temporal origin which the observations were designed to test. No decisive observation enables us to distinguish between theories of a temporal origin of the universe and the theories of infinite time (continuous creation); the aspects of the galaxies offer no test of either theory without invoking additional assumptions. Curvature of time (...) is rejected as being a complication at present scientifically unnecessary, as is also the hypothesis of continuous creation. The view maintained is that the temporal theory based on linear extrapolation is acceptable until it be disproved. Various new techniques which may be useful in attempting to refute this theory are discussed. (shrink)

It has been a common assumption that words are substances that instantiate or have properties. In this paper, I question the assumption that our ontology of words requires posting substances by outlining a bundle theory of words, wherein words are bundles of various sorts of properties (such as semantic, phonetic, orthographic, and grammatical properties). I argue that this view can better account for certain phenomena than substance theories, is ontologically more parsimonious, and coheres with claims in linguistics.